idcrypt - Design Therapeutics has outlined a definitive timeline for initiating patient dosing of DT-818 in the first half of 2026, establishing a clear milestone for its DM1 drug development strategy. The announcement answers the essential What, Why, and How by confirming regulatory preparation, clinical objectives, and financial capability to pursue early human testing. Investors and analysts now have a solid benchmark to track as the company advances its lead genetic therapy candidate. The focus of the upcoming Phase 1 study is Myotonic Dystrophy Type-1, a rare neuromuscular disorder with significant unmet medical need. Design Therapeutics intends to run the multiple-ascending-dose trial in Australia, leveraging a regulatory pathway that often allows for more efficient first-in-human approvals. This structure positions the company to generate foundational safety and pharmacodynamic data that will influence all downstream decisions. Notably, the company emphasizes that DT-818 is b...
BlackRock Clients Dump Bitcoin as Price Hits $81,900
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idcrypt - Bitcoin fell sharply to $81,900 on Friday, erasing Thursday’s recovery and deepening a month-long downturn that has wiped more than $1.4 trillion from the total cryptocurrency market. The drop marks a painful reversal for traders who expected the asset to recover after weeks of volatility driven by macroeconomic uncertainty. The crypto market now sits below the $3 trillion threshold, signaling a notable shift in sentiment from late October’s optimism. The decline raises a critical question: why are institutional and retail investors running for the exit at this stage?
Analysts point to a growing risk-off environment triggered by economic instability and the fallout from the longest U.S. government shutdown in history. Citrini Research issued a sharp warning that speculative assets including Bitcoin will likely remain under pressure until mid-December. The report suggests that volatility will continue dominating market behavior until macroeconomic conditions stabilize. Meanwhile, blockchain ecosystems and decentralized finance sectors are experiencing reduced inflows as investors prefer safer positions during heightened uncertainty.
The situation escalated when shocking ETF data emerged. Investors withdrew $548 million from Bitcoin exchange-traded funds on Thursday alone, bringing November’s outflows to $3.77 billion according to DefiLlama. The largest hit came from BlackRock’s iShares Bitcoin Trust, which saw clients dump $355 million, making November its worst performance since February. Tokenomics sentiment linked to institutional inflows has collapsed, and analysts believe sentiment could deteriorate further if selling pressure accelerates.
Notably, Robert Le, head of research at Kiln, argued that Bitcoin may be decoupling from its historical four-year halving cycle model that many traders previously treated like gospel. The idea that Bitcoin follows a predictable cadence has shaped market psychology for years, but institutional adoption, derivatives growth, and high-speed global liquidity flows may be transforming price behavior. If true, this would imply that both upside expectations and downside risks have been underestimated — a possibility that has fueled panic rather than confidence.
The macro environment adds another layer of difficulty. September’s delayed U.S. jobs report delivered complicated results: 119,000 jobs added versus 51,000 expected, yet unemployment ticked up to 4.4%. These conflicting signals pushed investors into confusion over whether the Federal Reserve will cut rates in December. Historically, lower rates boost appetite for digital assets, but hawkish comments from key Fed members have clouded the outlook further. The CME FedWatch tool now places the odds of a December rate cut at just 35%, down from earlier optimism, mirroring a similar prediction gap seen on Polymarket.
Meanwhile, disagreements within the Federal Reserve are widening, adding fuel to uncertainty. Philadelphia Fed President Anna Paulson issued a cautionary stance on rate cuts, while Fed Governor Michael Barr warned inflation remains too high to justify aggressive easing. The combination of unclear policy direction and volatile macroeconomic data has pressured both traditional and blockchain-based financial markets, emphasizing the deep correlation between institutional finance and digital assets.
The selloff extends far beyond crypto. U.S. equities experienced one of the most dramatic intraday reversals in years, highlighting broad risk aversion across markets. Nvidia surged 5% early Thursday before collapsing to a 3.1% loss, reigniting speculation that AI-linked valuations may be overheating. The Nasdaq dropped 2.1%, the S&P 500 fell 1.5%, and the Dow slid 380 points — signaling economic confidence remains fragile.
Across exchanges, liquidations hit $2 billion in 24 hours, a sign that leveraged traders were caught off-guard by rapid price swings. Bitcoin fell 10.8% over the same period, while Ethereum mirrored the downturn with a 10.9% drop to roughly $2,700. Governance tokens, decentralized finance assets, and altcoins suffered comparable declines as liquidity dried up. Notably, derivatives funding rates flipped deeply negative, showing traders are aggressively betting on more downside.
Despite today’s turbulence, some analysts argue the downturn may represent a healthy correction rather than structural collapse. Institutional vehicles remain active, blockchain adoption continues advancing, and tokenomics structures backing major protocols remain intact. However, sentiment remains fragile, and until macro signals turn decisively supportive, volatility will continue as the dominant trend. If ETF outflows accelerate, the selloff could enter a second phase — one that tests long-term investor conviction.
As markets digest rapid shifts, one thing is clear: Bitcoin’s price behavior is evolving. Whether this marks the beginning of a new maturity phase or simply another brutal cycle shakeout remains uncertain. For now, analysts warn that the path forward may become bumpier before stability returns — and traders should brace for more chaos. Humorously put: Bitcoin may be decentralized, but fear remains extremely well-coordinated.
Sources
DL News
DefiLlama
Bloomberg
CME FedWatch
Bureau of Labour Statistics
Hariyanto
Crypto Blogger & NFT Artist Founder of idcrypt.xyz & ARDION
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