idcrypt - Design Therapeutics has outlined a definitive timeline for initiating patient dosing of DT-818 in the first half of 2026, establishing a clear milestone for its DM1 drug development strategy. The announcement answers the essential What, Why, and How by confirming regulatory preparation, clinical objectives, and financial capability to pursue early human testing. Investors and analysts now have a solid benchmark to track as the company advances its lead genetic therapy candidate. The focus of the upcoming Phase 1 study is Myotonic Dystrophy Type-1, a rare neuromuscular disorder with significant unmet medical need. Design Therapeutics intends to run the multiple-ascending-dose trial in Australia, leveraging a regulatory pathway that often allows for more efficient first-in-human approvals. This structure positions the company to generate foundational safety and pharmacodynamic data that will influence all downstream decisions. Notably, the company emphasizes that DT-818 is b...
Binance Refutes Claims of Ignoring Crypto Financial Crimes
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idcrypt - The cryptocurrency sector faces scrutiny again as the International Consortium of Investigative Journalists (ICIJ) revealed that major exchanges, including Binance and OKX, processed billions of dollars linked to illicit activities. Central to the report is Huione, a Cambodia-based exchange blacklisted by the U.S. Treasury for laundering digital assets associated with North Korean hackers and Southeast Asian scam centers. This exposes ongoing challenges in blockchain governance and compliance.
From July 2024 to July 2025, Binance reportedly processed over $400 million from Huione, while OKX received $220 million over five months. Despite the numbers, Binance insists that these flows represent a fraction of its tokenomics ecosystem, emphasizing robust monitoring systems that flag suspicious transactions in real time.
A Binance spokesperson told DL News, “It is categorically false that Binance turns a blind eye to criminal activity.” The company cites analytics from Chainalysis and TRM Labs showing a 98% reduction in exposure to illicit funds since 2023, reflecting strengthened governance and compliance structures.
Binance’s past compliance failures are well-documented. In 2023, the exchange pleaded guilty to insufficient AML measures, resulting in a $4.3 billion DOJ fine and the imposition of a three-year independent monitor to ensure regulatory adherence. These measures highlight the importance of operational transparency in tokenomics and blockchain security.
While exchanges cannot fully prevent onboarding of customers who may move illicit funds, Binance emphasizes that its systems enable transaction monitoring, account restrictions, and fund freezing when necessary. These proactive strategies mirror traditional financial institutions but leverage blockchain analytics for better oversight.
OKX, the fifth-largest global exchange by volume, stated that the reported flows constitute a minor portion of total activity. The exchange maintains evolving AML/KYC and governance protocols aligned with regulatory expectations, demonstrating how compliance evolves alongside blockchain innovations.
Following the Treasury’s October 2025 blacklist of Huione, OKX paused all interactions with the exchange. Both Binance and OKX illustrate how crypto platforms are integrating sophisticated risk management into their operational frameworks while sustaining liquidity for legitimate users.
The ICIJ investigation signals broader issues in blockchain transparency and financial crime detection. Criminal actors exploit gaps in cross-border regulations, highlighting the challenges of policing a decentralized financial ecosystem where token flows are pseudonymous and global.
Ari Redbord of TRM Labs emphasized the complexity of blockchain intelligence: many addresses linked to bad actors are also used legitimately, and intermediaries like OTC desks, mixers, and peer-to-peer hubs handle both licit and illicit transactions. Effective governance and analytics are crucial to distinguish these flows.
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Comparing crypto with traditional finance, the UN estimates $2 trillion in illicit funds laundered annually through conventional banking, while Chainalysis reports $189 billion in illicit cryptocurrency flows over five years. These figures suggest that while blockchain presents risks, its transparent ledger allows for stronger investigative tools and governance improvements.
Regulatory fragmentation complicates enforcement. Different jurisdictions maintain distinct AML/KYC and financial crime rules, creating loopholes that sophisticated actors exploit. Consequently, exchanges must continually upgrade compliance frameworks to mitigate risks and adhere to global standards of blockchain governance.
As digital finance matures, the report highlights the need for collaboration among exchanges, regulators, and analytics firms to uphold trust in tokenomics, safeguard users, and prevent illicit flows from undermining the credibility of decentralized finance. Crypto platforms must demonstrate both technical and regulatory vigilance to sustain market integrity.
Sources:
ICIJ Investigations, U.S. Treasury Department, FinCEN, DL News, Chainalysis, TRM Labs, UN Reports, Department of Justice
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